MV Agusta F4 1000 R is the second mass-produced F4 1000, the F4 1000 R and F4 1000R CRC Gold limited edition, was released in 2006 and came with a 174-horsepower - 175 horsepower and 308 km/h for limited edition (128 kW) engine. The F4 1000 R also has upgraded Brembo Monobloc radial brakes, forged black Brembo wheels, a carbon-nitride coated Marzocchi upside down fork and an upgraded Sachs rear shock absorber (compression & rebound damping adjustable in high & low speed range). The F4 1000 R engine does not utilize the TSS system. A 1+1 (Biposto) version is available that adds a pillion for a passenger. In August 2006 an F4 1000 R was used to set a record for the fastest production class 1000 cc motorcycle of over 185.882 mph (299.148 km/h) at Bonneville Salt Flats.
Data of the MV Agusta F4 1000 R was added in the Fifth Anniversary Update, and the bike was eventually released in the Halloween Update as a high-end Class C motorcycle with the following rank statistics:
- Starting rank: 1184
- MAX rank: 1436 (+252)
- MAX+PRO rank: 1582 (+146)
- Tuning Kit bonus: +44
- Stock to MAX+PRO rank difference: 398
- Upgrade rank percentages: 25/25/25/25
- Nitro Efficiency: 8/11/14
The MV Agusta F4 1000 R is the fastest Class C bike, being able to reach 409.5 km/h (254.3 mph) at MAX+PRO without a Tuning Kit. With a Tuning Kit it reaches 423.1 km/h (262.7 mph). With a strong supercharged boost giving it a further increased total speed of 471.1 km/h (292.6 mph), even higher than the current fastest Class B car, the Mazda RX-8 Special Edition, the F4 can compete with the Sbarro Sparta and Maserati Alfieri. It also has very good acceleration, handling and drifting, as well as a decent nitro efficiency.
At MAX+PRO, the MV Agusta F4 dominates on tracks where the Alfieri, Sparta, and Alpine were once dominant on.
As of the 2019 Spring Update, upgrades cost 1,560,000 while Pro Kits require 521,600, 40 of each Class C Motorcycle Part, 72 Common Techs, 60 Four-Stroke Engines, and 28 Rare Techs.